The Department of Pathology

Our staff Selected publications Русская версия

The Department of Pathology of Russian Children’s Clinical Hospital (RCCH) is a place of clinical and pathology practice, research, and continuing education. We have modern equipment and highly qualified staff in order to perform all routine morphological procedures: histology (H&E), histochemistry, immunohistochemistry, and immunofluorescence. RCCH has over 1,000 beds and a lot of departments such as hematological, oncological, gynecological, endocrinological and a department for bone marrow and kidney transplantation, among others. We have more than 3,000 different cases per year. The range of histologic material is very broad.

Our prioritized areas of interests are:

• Soft Tissue and Bone Pathology
• Central Nervous System Pathology
• Liver pathology including tumors, developmental abnormalities, inflammatory and metabolic disorders
• Gastrointestinal pathology in children and adolescents
• Genitourinary pathology in children and adolescents
• Nephropathology (glomerulopathies, tubulopathies, etc.)
• Vascular malformations and tumors
• Dermatopathology (tumors, nevi, autoimmune conditions)
• Adrenal pathology
• Lymphomas
• Lung pathology including tumors and developmental abnormalities
• Rare endocrine disorders

Our staff

Dr. Dmitrii Rogozhin
Head of Pathology Department, MD, PhD

• E-mail: rogozhin@rdkb.ru, pathol.rogozhind@gmail.com
• Education:
• Izhevsk State Medical Academy, 1994–2000, Izhevsk, Russia
• Izhevsk State Medical Academy, 2000–2002, Izhevsk, Russia: 2-year postgraduate program (ordinatura) in Pediatrics
• Russian Medical Academy of Postgraduate Education, 2002, Moscow, Russia: Professional training in Pathological Anatomy (Pathology)
• Research Institute of Human Morphology, Russian Academy of Medical Science, 2003–2006, Moscow, Russia: Doctorate in Medicine (Russian “Candidate of Sciences”, equivalent to PhD in Medicine). Thesis: “Single umbilical artery as the risk factor of congenital developmental abnormalities in life-born infants”, supervised by A.P. Milovanov, MD, PhD
• Department of Pathology, St. Jude Children's Research Hospital, 2007, Memphis, TN, USA: Further training program for doctors, included practical training in soft tissue and pediatric pathology and a presentation on research done at my hospital (rare cases of colorectal carcinoma in children)
• Rizzoli Orthopedic Institute, 2013-2017, Bologna, Italy: Course on Musculoskeletal Pathology (a yearly 4-day update on bone and soft tissue tumors with emphasis on clinical-pathologic and radiologic correlations, includes practical studies)
• Pirogov Russian National Research Medical University, 2016-2019, Moscow, Russia: Advanced Doctorate in Medicine (“Doctor of Sciences”, the highest academic degree in Russia). Thesis: “A differential diagnosis of the giant cell lesions of bone in children”
• Memberships and Assotiations:
• International Skeletal Society (Since 2015)
• Russian Society of Pathologists (RSP)
• USCAP (Since 2018)
• Research Interests: Pediatric pathology, soft tissue and bone pathology

Dr. Anastasiia Shekhtman
MD

• Education:
• First Moscow State Medical University, Medical Faculty, 2004–2010, Moscow, Russia
• N.V.Sklifosovsky Research Institute of Emergency Medicine, 2010–2012, 2-year postgraduate program in Pathology Department, Moscow, Russia
• Rizzoli Orthopedic Institute, 2017, Bologna, Italy: Course on Musculoskeletal Pathology (a yearly 4-day update on bone and soft tissue tumors with emphasis on clinical-pathologic and radiologic correlations, includes practical studies)
• Observership in Neuropathology department, 2017, UKE, Hamburg, Germany
• Observership in Dermatopathology department, 2019, USCF, San Francisco, USA
• Pirogov Russian National Research Medical University, 2019-present, Moscow, Russia
• Doctorate in Medicine (Russian “Candidate of Sciences”, equivalent to PhD in Medicine). Thesis: “Morphological diagnosis of intracranial chondroid tumors”, supervised by D. Rogozhin, MD, PhD (in progress)
• Research Interests: Neuropathology, bone pathology

Dr. Irina Kletskaya
Pathologist, MD

• E-mail: kletskaya@rdkb.ru, ikletskaya@gmail.com
• Education:
• Belarusian State Medical University, Pediatric department, 2005–2011 Minsk, Belarus
• Belarusian Research Center for Pediatric Oncology, Hemathology and Immunology Internship in Pathology July 2011 – July 2012 Minsk, Belarus
• International Paediatric Pathology Association (IPPA) Advanced Course in Paediatric Pathology 2013-2017
• IPPA Update Course in Paediatric Pathology (2015)
• Mariane Malone Memorial Advanced Course in Paediatric Pathology, 2017 Dublin, Ireland
• Training at the Dermatopathology Training Center, Biopticka Lab, 2017 Plzen, Czech Republic
• Ivo Leuschner Memorial Advanced Course in Paediatric Pathology, 2019 Catania, Sicily
• Memberships and Assotiations:
• Paediatric Pathology Society — Committee member (2019–2022)
• SIOP-RTSG
• Research Interests: Vascular anomalies, melanocytic proliferations, kidney tumors, endocrine pediatric tumors, soft tissue pathology, salivary gland pathology

Dr. Berta Kushnir
Pathologist, MD

• E-mail: kushnir@rdkb.ru, kushnir.berta@gmail.com
• Education:
• Pirogov Russian National Research Medical University, 2006-2012, Moscow, Russia
• Pirogov Russian National Research Medical University, 2012-2013, Moscow, Russia: 1-year postgraduate program (internship) in Pediatrics
• Pirogov Russian National Research Medical University, 2013-2015, Moscow, Russia: Professional training in Pathological Anatomy (Pathology)
• International Course on Native and Transplant Renal Biopsy Interpretation, Ljublyana, June 5-7, 2014
• 9th European Renal Pathology Course, Amsterdam, Holland, June 9-12, 2015
• ECCO Congress 2016, H-ECCO IBD masterclass, Amsterdam, Netherlands, March 16-19, 2016
• Surgical Pathology of the Gastrointestinal tract, Austin, TX (USA), May 10-14, 2016
• The Nephrology Days, Moscow, Russia, October 27-29, 2016
• The ISN-ANIO Clinical Nephropathology Certificate Program (online), January 1, 2017 – December 31, 2017
• IPPA Advanced course in paediatric pathology, Venice, Italy, September 30 – October 6, 2017
• IPPA Advanced course in paediatric pathology, Sheffield, UK, September 22-28, 2018
• IPPA Advanced course in paediatric pathology, Lisbon, Portugal, September 21-27, 2019
• Renal and Transplantation Pathology Meeting, Rotterdam, Netherlands, November 15-16, 2019
• ECCO Congress 2020, H-ECCO IBD masterclass, Vienna, Austria, February 12-15, 2020

Dr. Dmitry Konovalov
Pathologist, MD, PhD

• Education:
• 2004 PhD Pediatric Hematology Research Institute, Moscow, Russia
• 2005 International Outreach Program (Pathology) at St. Jude Children’s RH, Memphis, TN (USA)
• 2006–2007 Pathology Fellowship at I.M. Sechenov First Moscow State Medical University, Russia
• 2001–2003 Post-graduate training (residency) in Pediatric Medicine at Pediatric Hematology Research Institute, Moscow, Russia
• 1995–2001 MD in Pediatric Medicine at Pirogov Russian National Research Medical University, Moscow, Russia
• Research Interests: Aggressive lymphomas, lymphomas in immunodeficiency, soft tissue tumors

Dr. Dmitry Abramov
Pathologist, MD

Dr. Vitaly Roshchin
Pathologist, MD

• Education:
• 2002–2009 MD in Pediatric Medicine at Pirogov Russian National Research Medical University, Moscow, Russia
• 2009–2010 1-year residency in general pathology. Russian State Medical University
• 2010–2011 Postgraduate course in pediatrics oncological pathology. Kiel, Germany
• Training on immunohistochemical techniques. Ventana Training Center (Grenoble, France)
• III National Pediatric Pathology School. Moscow, Russia
• 2011–2019 Postdoc course on soft tissue and bone tumors pathology
• Research Interests: Pediatric oncological pathology, soft tissue and bone tumors

Dr. Anna Mitrofanova
Pathologist, MD

Dr. Alexey Kislyakov
Pathologist, MD

Ekaterina Chumicheva
Head of Laboratory Technician

• Education: Russian New University (2007–2012)

Ekaterina Malakhova
Laboratory Technician

• Education: Moscow 1st Medical College

Ludmila Tiptsova
Laboratory Technician

• Education: Moscow 7th Medical College (1978–1980)

Medzhidova Khadizha
Laboratory Technician

• Education: Moscow 1st Medical College (2015–2019)

Selected publications

• Bolshakov N, Artemov A, Vorochai A, et al. Endoprosthesis reconstruction as a surgical treatment of children and adolescence with bone tumors around the knee [in Russian]. Voprosy gematologii, onkologii i immunopatologii v pediatrii (Pediatric Hematology/Oncology and Immunopathology). 2019;18(1):55-61. doi:10.24287/1726-1708-2019-18-1-55-61
• Kugushev A, Lopatin A, Yasonov S, Rogozhin D. Fibrous and bone lesions of the jaws in children [in Russian]. Golova i sheya (Head and Neck). 2018;(4):6-14
• Rogozhin D, Konovalov D, Bolshakov N, Talalaev A, Kozlov A, Kuzin A. Aneurismal bone cyst in children and adolescents [in Russian]. Voprosy gematologii, onkologii i immunopatologii v pediatrii (Pediatric Hematology/Oncology and Immunopathology). 2017;16(2):33-39
• Rogozhin D, Konovalov D, Talalaev A, et al. Non-ossifying fibroma (metaphyseal fibrous defect): analysis of 35 cases and review of the literature [in Russian]. Arkhiv Patologii (Archive of Pathology). 2016;78(2):36-40
• Rogozhin D, Konovalov D, Vanel D, et al. Malignant solitary fibrous tumor of the sacrum: a case report. J. Cancer Res. Ther. 2015;3(4):52-55
• Rogozhin D, Bertoni F, Vanel D, et al. Benign fibro-osseous lesions of the craniofacial area in children and adolescents: a review. Arkhiv Patologii (Archive of Pathology). 2015;77(4):63-70
• Rogozhin D, Boulytcheva I, Kushlinskiy N, et al. Osteochondroma in children and adolescents [in Russian]. Arkhiv Patologii (Archive of Pathology). 2015;77(3):37-40
• Rogozhin D, Boulytcheva I, Kushlinskiy N, et al. Osteosarcoma in children and adolescence [in Russian]. Sarkomy kostey, myagkikh tkaney i opukholi kozhi (Bone and Soft Tissue sarcomas and Skin Tumors). 2014;(2):9-18
• Rogozhin D, Boulytcheva I, Talalaev A, Konovalov D, Ektova A, Roshin V. Bone lesions in children and adolescence [in Russian]. Voprosy biologicheskoy meditsinskoy i farmatsevticheskoy khimii (The questions of biological, medical and pharmaceutical chemistry). 2014;(8):66-70
• Rogozhin D, Boulytcheva I. Juvenile ossifying fibroma in children: problems in differential diagnosis [in Russian]. Sarkomy kostey, myagkikh tkaney i opukholi kozhi (Bone and Soft Tissue sarcomas and Skin Tumors). 2014;(1):70-73
• Benign Fibro-Osseous Lesions of the Craniofacial Area in Children and Adolescents: A Review. Rogozhin DV, Bertoni F, Vanel D, Gambarotti M, Righi A, Boulytcheva IV, Konovalov DM, Talalaev AG, Roshin VY, Ektova AP, Bolotin MV, Lopatin AV.; Arkh Patol. 2015 Jul-Aug;77(4):63-70. Review
• Brentuximab vedotin in the treatment of a patient with refractory Hodgkin disease and Proteus syndrome - a case report and discussion. Myakova N, Smirnova N, Evstratov D, Abugova Y, Balashov D, Diakonova Y, Konovalov D, Skvortsova Y, Maschan A. Clin Case Rep. 2015 Jul;3(7):646-9. doi: 10.1002/ccr3.297. Epub 2015 Jun 11
• Osteochondroma in children and adolescents Rogozhin DV, Bulycheva IV, Kushlinsky NE, Konovalov DM, Talalaev AG, Roshchin VY, Ektova AP, Kushnir BL, Kuzin AS, Bologov AA. Arkh Patol. 2015 May-Jun;77(3):37-40. Russian
• Subcutaneous panniculitis-like T-cell lymphoma in children: a detailed clinicopathological description of 11 multifocal cases with a high frequency of haemophagocytic syndrome.Oschlies I, Simonitsch-Klupp I, Maldyk J, Konovalov D, Abramov D, Myakova N, Lisfeld J, Attarbaschi A, Kontny U, Woessmann W, Klapper W.Br J Dermatol. 2015 Mar;172(3):793-7. Epub 2015 Feb 5
• Malignant rhabdoid tumor of the liver presented with initial tumor rupture. Kachanov D, Teleshova M, Kim E, Dobrenkov K, Moiseenko R, Usychkina A, Filin A, Semenkov A, Mitrofanova A, Konovalov D, Shamanskaya T, Novichkova G, Varfolomeeva S.; Cancer Genet. 2014 Sep;207(9):412-4. Epub 2014 Apr 21
• Therapy of advanced-stage mature B-cell lymphoma and leukemia in children and adolescents with rituximab and reduced intensity induction chemotherapy (B-NHL 2004M protocol): the results of a multicenter study. Samochatova EV, Maschan AA, Shelikhova LN, Myakova NV, Belogurova MB, Khlebnikova OP, Shamardina AV, Ryskal OV, Roumiantseva JV, Konovalov DM, Dubrovina ME, Rumyantsev AG. Pediatr Hematol Oncol. 2014 Jul;36(5):395-401
• Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Abramov D, Oschlies I, Zimmermann M, Konovalov D, Damm-Welk C, Wössmann W, Klapper W. Haematologica. 2013 Oct;98(10):1547-53. doi: 10.3324/haematol.2013.085837. Epub 2013 May 28. Atypical teratoid/rhabdoid tumors of childhood. Mitrofanova AM, Konovalov DM, Kisliakov AN, Roshchin VIu, Abramov DS. Arkh Patol. 2013 Sep-Oct;75(5):36-42. Russian
• Turcot syndrome. Rare observation and literature review. Ozerov SS, Zakharov IV, Talypov SR, Konovalov DM, Kisliakov AN, Kachanov DIu, Zheludkova OG, Varfolomeeva SR, Rachkov VE. Zh Vopr Neirokhir Im N N Burdenko. 2013;77(3):49-53; discussion 53. Review
• Sarcomatoid carcinoma of the thymus. Rogozhin DV, Konovalov DM, Andreeva MA, Samoĭlov DA, Kunitsin AG, Savkova RF, Konstantinova MM. Arkh Patol. 2010 Mar-Apr;72(2):34-5. Review. Russian
• First report of effective and feasible treatment of multifocal lymphangiomatosis (Gorham-Stout) with bevacizumab in a child. Grunewald TG, Damke L, Maschan M, Petrova U, Surianinova O, Esipenko A, Konovalov D, Behrends U, Schiessl J, Wörtler K, Burdach S, von Luettichau I. Ann Oncol. 2010 Aug;21(8):1733-4. doi: 10.1093/annonc/mdq331. Epub 2010 Jul 6
• Transforming growth factor as a marker beta of nephrogenetic disturbance in congenital obstructive uropathies. Leonova LV, Severgina ES, Popova OP, Konovalov DM, Petruchina IV, Simonova NA. Arkh Patol. 2007 Jul-Aug;69(4):35-8. Russian
• Morphological and immunohistogenetical features of colon cancer in children. Talalaev AG, Tertychnyĭ AS, Konovalov DM, Val'kov AIu, Marenich NS. Arkh Patol. 2006 May-Jun;68(3):31-5. Russian
• Variants of formation of v. testicularts sinistra in children with varicocele. Severgina ES, Leonova lV, Konovalov DM, Pykov MI, Kondakov VT, Sporius RM.; Arkh Patol. 2006 Jan-Feb;68(1):33-5. Russian
• Morphological features of juvenile colon polyps in children.Tertychnyĭ AS, Konovalov DM, Talalaev AG; Arkh Patol. 2004 Jan-Feb;66(1):28-31. Russian
• Sidorov, I. V., Kletskaya, I. S., Konovalov, D. M. (2020). Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children. Arkhiv Patologii, 82(2), 43-51. doi:10.17116/patol20208202143
• Radygina, S. A., Kletskaya, I. S., Kostareva, I. O., Mitrakov, K. V., Kozlovskaya, S. N., Ershov, N. M., . . . Balashov, D. N. (2020). Atypical aggressive development of pigmented epithelioid melanocytoma in patient with fanconi anemia after hematopoietic stem cell transplantation. Pediatric Hematology/Oncology and Immunopathology, 19(2), 166-169. doi:10.24287/1726-1708-2020-19-2-166-169
• Salgado, C. M., Zin, A., Garrido, M., Kletskaya, I., DeVito, R., Reyes-Múgica, M., . . . Alaggio, R. (2020). Pediatric soft tissue tumors with BCOR ITD express EGFR but not OLIG2. Pediatric and Developmental Pathology, doi:10.1177/1093526620945528
• Sagoyan, G. B., Usychkina, A. Y., Kletskaya, I. S., Vorozhtsov, I. N., Kobyzeva, D. A., Gornostaev, V. V., . . . Nechesnyuk, A. V. (2018). Sinonasal renal cell-like adenocarcinoma. Pediatric Hematology/Oncology and Immunopathology, 17(4), 57-63. doi:10.24287/1726-1708-2018-17-4-57-63
• Hachatryan, L. A., Kletskaya, I. S., & Orekhova, E. V. (2019). Syndromе associated with multiple venous malformations (Bean syndrome). Pediatric Hematology/Oncology and Immunopathology, 18(3), 78-87. doi:10.24287/1726-1708-2019-18-3-78-87
• Kletskaya I.S., Rogozhin D.V., Konovalov D.M., Ektova A.p., Kushnir B.L. Morphological diagnosis and assessment of the malignant potential in pediatric adrenal cortical neoplasms. Pediatric Hematology/Oncology and Immunopathology. 2018;17(3):111-119. (In Russ.) https://doi.org/10.24287/1726-1708-2018-17-3-111-119
• Smetanina, Nataliya & M. Konovalov, D & S. Kletskaya, I & P. Scherbakov, A & Talypov, Sergey & N. Merkulov, N & R. Varfolomeeva, S. (2017). Littoral cell angioma. Pediatria. Journal named after G.N. Speransky. 96. 228-233. 10.24110/0031-403X-2017-96-3-228-233
• Rogozhin DV, Moiseev SN, Kozlov AS, Kletskaya IS and Ektova AP: Case 45: Osteogenesis Imperfecta Type 5, Annual Meeting of the International Skeletal Society, New York, USA, 2017
• Uskova N.G., Kletskaya I.S., Shamanskaya T.V., Kachanov D.Yu., Tereshchenko G.V., Feoktistova E.V., Sugak A.B., Basalay T.V., Likar Yu.N., Raykina E.V., Mersiyanova I.V., Varfolomeeva S.R. A case of adrenal cortical adenoma in 14-year-old boy. Russian Journal of Pediatric Hematology and Oncology. 2016;3(3):66-69. (In Russ.) https://doi.org/10.17650/2311-1267-2016-3-3-66-69
• Kletskaya, I., A. S. Portaynko, and J. V. Gorgun. "Expression of tissue transglutaminase in small intestine biopsy specimens in coeliac disease." European Journal Of Medical Research. Vol. 14. 236 2009
• Ektov D.B., Pykov M.I., Valov A.L., Molchanova M.S., Kushnir B.L., Martynenkova A.V. Hemodynamics in renal transplant in children with various morphological changes in the long-term post-transplant period. Meditsinskiy sovet = Medical Council. 2021;(1):286-293. (In Russ.) https://doi.org/10.21518/2079-701X-2021-1-286-293
• A.Rumyantsev, A.Bologov, O.Borisova, J.Kashirina, B.Kushnir, E.Molchanova, A.Valov. Rituximab in induction immunosuppressive therapy as a prevention of the recurrent FSGS after kidney transplantation in children, single center experience. IPNA Congress Venice 2019. Abstract #471 and Poster
• G.V.Kozyrev, D.T. Manasherova, G.A. Abdulkarimov, F.K. Abdullaev, V.V. Nikolaev MD PhD, M.A. Gazimiev MD, PhD. Comparative histological analysis of grafts for urethroplasty in children with proximal forms of hypospadias: preputial skin vs buccal mucosa. Urology 2019(6):87-91. DOI: https://dx.doi.org/10.18565/urology.2019.6.87-91
• E.K. Petrosyan, E.V. Pushkareva, B.L. Kushnir, P.E. Povilaitite, P.V. Shumilov. Lobular glomerulopathy: is it always membranoproliferative glomerulonephritis? Nephrology and Dialysis 2018(20):324-328. DOI: 10.28996/2618-9801-2018-3-324-328
• Aver’ianova Iu.V., Povolotskaya I.S., Kushnir B.L., Petrov D.A., Stepanov A.E., Makarov S.P., Ermolaeva A.A., Zaklyazminskaya E.V. Sclerosing encapsulating peritonitis in a child with X-linked immune dysregulation syndrome, polyendocrinopathy and enteropathy (IPEX). Clinical and Experimental Surgery. Petrovsky journal 2018;6(2):80-86. doi: 10.24411/2308-1198-2018-12011
• Ionov A.L., Gogina A.A., Sulavko Ya.P., Kushnir B.L. Full-thickness colon biopsy in diagnostics of Hirschsprung’s disease in children. Detskaya khirurgiya (Russian Journal of Pediatric Surgery). 2017; 21(6): 291-294. (In Russ.). DOI: http//dx.doi.org/10.18821/1560-9510-2017-21-6-291-294